α-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus
Identifieur interne : 001540 ( Main/Exploration ); précédent : 001539; suivant : 001541α-2-Macroglobulin in Saliva Is Associated with Glycemic Control in Patients with Type 2 Diabetes Mellitus
Auteurs : Juan Pablo Aitken [Chili] ; Carolina Ortiz [Chili] ; Irene Morales-Bozo [Chili] ; Gonzalo Rojas-Alcayaga [Chili] ; Mauricio Baeza [Chili] ; Caroll Beltran [Chili] ; Alejandro Escobar [Chili]Source :
- Disease Markers [ 0278-0240 ] ; 2015.
Abstract
Url:
DOI: 10.1155/2015/128653
PubMed: 25821337
PubMed Central: 4363888
Affiliations:
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sortKey="Baeza, Mauricio" sort="Baeza, Mauricio" uniqKey="Baeza M" first="Mauricio" last="Baeza">Mauricio Baeza</name><affiliation wicri:level="1"><nlm:aff id="I3">Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Beltran, Caroll" sort="Beltran, Caroll" uniqKey="Beltran C" first="Caroll" last="Beltran">Caroll Beltran</name><affiliation wicri:level="1"><nlm:aff id="I4">Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 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Juan Pablo" uniqKey="Aitken J" first="Juan Pablo" last="Aitken">Juan Pablo Aitken</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Ortiz, Carolina" sort="Ortiz, Carolina" uniqKey="Ortiz C" first="Carolina" last="Ortiz">Carolina Ortiz</name><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Morales Bozo, Irene" sort="Morales Bozo, Irene" uniqKey="Morales Bozo I" first="Irene" last="Morales-Bozo">Irene Morales-Bozo</name><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Rojas Alcayaga, Gonzalo" sort="Rojas Alcayaga, Gonzalo" uniqKey="Rojas Alcayaga G" first="Gonzalo" last="Rojas-Alcayaga">Gonzalo Rojas-Alcayaga</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Baeza, Mauricio" sort="Baeza, Mauricio" uniqKey="Baeza M" first="Mauricio" last="Baeza">Mauricio Baeza</name><affiliation wicri:level="1"><nlm:aff id="I3">Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Beltran, Caroll" sort="Beltran, Caroll" uniqKey="Beltran C" first="Caroll" last="Beltran">Caroll Beltran</name><affiliation wicri:level="1"><nlm:aff id="I4">Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Hospital Clínico, Servicio de Gastroenterología, Facultad de Medicina, Universidad de Chile, 8300456 Santiago</wicri:regionArea><wicri:noRegion>8300456 Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Escobar, Alejandro" sort="Escobar, Alejandro" uniqKey="Escobar A" first="Alejandro" last="Escobar">Alejandro Escobar</name><affiliation wicri:level="1"><nlm:aff id="I1">Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago</wicri:regionArea><wicri:noRegion>8380492 Santiago</wicri:noRegion></affiliation></author></analytic><series><title level="j">Disease Markers</title><idno type="ISSN">0278-0240</idno><idno type="eISSN">1875-8630</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Background</italic>. Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that <italic>α</italic>-2-macroglobulin levels are elevated in diabetic patients. <italic>Methods</italic>. 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between <italic>α</italic>-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated. <italic>Results</italic>. We found a positive correlation between <italic>α</italic>-2-macroglobulin and HbA1c (<italic>r</italic> = 0.778 and <italic>P</italic> < 0.0001). Area under the receivers operating characteristic (ROC) curve of <italic>α</italic>-2-macroglobulin indicated a positive discrimination threshold of <italic>α</italic>-2-macroglobulin (AUC = 0.903, CI 95%: 0.847–0.959, <italic>P</italic> < 0.0001) to diagnose glycemic control. <italic>Conclusions</italic>. Our data strongly suggest that the level of saliva <italic>α</italic>-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hu, F B" uniqKey="Hu F">F. B. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmer, H K" uniqKey="Holmer H">H. K. Holmer</name></author><author><name sortKey="Ogden, L A" uniqKey="Ogden L">L. A. Ogden</name></author><author><name sortKey="Burda, B U" uniqKey="Burda B">B. U. 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Strauss</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Chili</li></country></list><tree><country name="Chili"><noRegion><name sortKey="Aitken, Juan Pablo" sort="Aitken, Juan Pablo" uniqKey="Aitken J" first="Juan Pablo" last="Aitken">Juan Pablo Aitken</name></noRegion><name sortKey="Baeza, Mauricio" sort="Baeza, Mauricio" uniqKey="Baeza M" first="Mauricio" last="Baeza">Mauricio Baeza</name><name sortKey="Beltran, Caroll" sort="Beltran, Caroll" uniqKey="Beltran C" first="Caroll" last="Beltran">Caroll Beltran</name><name sortKey="Escobar, Alejandro" sort="Escobar, Alejandro" uniqKey="Escobar A" first="Alejandro" last="Escobar">Alejandro Escobar</name><name sortKey="Morales Bozo, Irene" sort="Morales Bozo, Irene" uniqKey="Morales Bozo I" first="Irene" last="Morales-Bozo">Irene Morales-Bozo</name><name sortKey="Ortiz, Carolina" sort="Ortiz, Carolina" uniqKey="Ortiz C" first="Carolina" last="Ortiz">Carolina Ortiz</name><name sortKey="Rojas Alcayaga, Gonzalo" sort="Rojas Alcayaga, Gonzalo" uniqKey="Rojas Alcayaga G" first="Gonzalo" last="Rojas-Alcayaga">Gonzalo Rojas-Alcayaga</name><name sortKey="Rojas Alcayaga, Gonzalo" sort="Rojas Alcayaga, Gonzalo" uniqKey="Rojas Alcayaga G" first="Gonzalo" last="Rojas-Alcayaga">Gonzalo Rojas-Alcayaga</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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